Bioadhesives/Sealants

Post-operative reconnection of tissues is crucial for restoring adequate function and structure. The conventional standard of care for this purpose is using sutures, wires, and staples after surgical procedures. However, these traditional methods are met with several limitations that have caused problems in surgical procedures for decades. For example, the application of these bindings is time-consuming and may cause further tissue damage, as well as posing a risk of bacterial infection. In addition, they may not provide immediate or adequate seals to stop body fluid and air leakages. The use of adhesive biomaterials is a superior alternative for wound closure, due to the advantages that they offer over conventional approaches, including their simple and painless application and short implementation time. In this regard, various types of surgical materials have been used for sealing and reconnecting tissues or attaching devices to the tissues. These biomaterials must be equipped with properties well suited for the final application and anatomical parts involved in the medical intervention. Such properties include finely tuned mechanical stability, strong interfacial bonding strength, biodegradability, quick and simple application, tissue regeneration and antimicrobial capability in the case of wounds that have high risk of infection. Our group has engineered highly elastic, biocompatible and biodegradable tissue adhesives based on various extracellular matrix (ECM) proteins and hybrids or composites of them. These materials can be adjusted to meet the requirements for a variety of applications, including gules for anastomosis, air-tight lung sealants, nerve glue, adhesives for musculoskeletal tissue repair and dental applications, sprayable adhesives for wound healing, adhesive cardiopatches, and bioadhesives for cornea sealing and repair. These novel adhesives /glues are superior to existing sealant products on the market and may signify a paradigm shift in surgical sealants that can ultimately enable sutureless procedures.

Lab members working in this area: Ehsan Shirzaei Sani, Brian Walker, Sevena Baghdasarian

Related Papers:

  • Shirzaei Sani, A. Kheirkhah, D. Rana, Z. Sun, W. Foulsham, A. Sheikhi, A. Khademhosseini, R. Dana, N. Annabi, Sutureless repair of corneal injuries using naturally derived bioadhesive hydrogels, Science Advances, 2019, 5, eaav1281, DOI:10.1126/sciadv.aav1281.
  • E. Shirzaei Sani, R. Portillo-Lara, I. Noshadi, W. Yu, B. M. Geilich, A. Spencer, T. J. Webster, and N. Annabi, “Engineering adhesive hyaluronic acid/elastin like polypeptide hybrid hydrogels for tissue engineering applications”, ACS Biomaterials Science & Engineering, 2018, DOI: 10.1021/acsbiomaterials.8b00408.
  • J. R. Soucy, E. Shirzaei Sani, R. Portillo Lara, D. Diaz Vera, F. Dias, A. S. Weiss, A. N. Koppes, R. A. Koppes, N. Annabi, “Photocrosslinkable Gelatin/Tropoelastin Adhesives for Peripheral Nerve Repair”, Tissue Engineering, Part A, 2018, DOI: 10.1089/ten.TEA.2017.0502
  • N. Annabi, Y. Zhang, A. Assmann, E. Shirzaei, G. Cheng, A.D. Lassaletta, A. Vegh, B. Dehghani, G. U. Ruiz-Esparza, X. Wang, S. Gangadharan, A.S. Weiss, A. Khademhosseini, “Engineering a highly elastic human protein-based sealant for surgical applications”, Science Translational Medicine, 2017, 9, 410.
  • N. Annabi, D. Rana, E. Shirzaei Sani, R. Portillo-Lara, J. L. Gifford, M. M. Fares, S.M. Mithieux, A.S. Weiss, “Engineering a sprayable and elastic hydrogel adhesive with antimicrobial properties for wound healing”, Biomaterials, 2017, 139, 229-243.
  • A. Assmann, A. Vegh, M. Ghasemi-Rad, S. Bagherifard, G. Cheng, E. Shirzaei Sani, G.U. RuizEsparza, I. Noshadi, A. Lassaletta, S. Gangadharan, A. Tamayol, A. Khademhosseini, N. Annabi, “A highly adhesive and naturally derived sealant”, Biomaterials, 2017, 140, 115-127.