Drug/Gene Delivery

One aspect of our research is designing multifunctional biomolecule-based delivery platforms by combining our knowledge of biomaterials with nanotechnology, and microfabrication techniques. In our research, we aim to engineer different hydrogel-based biomaterials that can be used as advanced technologies for controlled delivery/release applications. We mainly focus on the delivery of biomolecules such as genes/proteins, drugs, antimicrobial agents for different biomedical applications (i.e. immunomodulation, wound healing, and ocular ulcers and diseases). These biomolecules can be directly loaded to the hydrogel carrier or can be incorporated into nanoparticles to enable the control release. We can control the biomolecule loading efficiency, delivery, and its release by tuning the hydrogel physical or biochemical properties. For example, the pore size of hydrogels significantly influences the rate at which drugs diffuse inside or outside the hydrogel network. Another example is by controlling the degradation rate of the hydrogel carrier, which subsequently results in a tunable release profile. In addition, nanoparticles based on biocompatible and biodegradable polymers are popular carriers for drug delivery purposes, since they offer high loading efficiency, precise controlling over release rate, and can degrade into non-toxic components and be eliminated via the metabolic pathway. It is also well known that the physicochemical properties of the encapsulated biomolecule substance contribute to the release rate. In our lab, we take advantage of these properties to develop advanced hydrogel-based delivery systems for localized delivery of biological active cues with minimal systemic toxicity.

Lab members working in this area: Ehsan Shirzaei Sani, Shima Gholizadaeh

Related Papers:

  • M. Farshbaf, R. Salehi, N. Annabi, R. Khalilov, A. Akbarzadeh, S. Davaran, pH-and thermo-sensitive MTX-loaded magnetic nanocomposites: synthesis, characterization, and in vitro studies on A549 lung cancer cell and MR imaging, Drug development and industrial pharmacy, 44(3), (2018), 452-462.
  • N. Asadi, N. Annabi, E. Mostafavi, N. Annabi, R. Khalilov, S. Saghfi, M. Mehrizadeh, A. Akbarzadeh, Synthesis, characterization and in vitro evaluation of magnetic nanoparticles modified with PCL–PEG–PCL for controlled delivery of 5FU, Artificial cells, nanomedicine, and biotechnology, doi.org/10.1080/21691401.2018.1439839, (2018), 1-8.
  • M. Farshbaf, S. Davaran, A. Zarebkohan, N. Annabi, A. Akbarzadeh, R. Salehi, Significant role of cationic polymers in drug delivery systems, Artificial cells, nanomedicine, and biotechnology, https://doi.org/10.1080/21691401.2017.1395344, (2017), 1-20.
  • N. Annabi, D. Rana, E. Shirzaei Sani, R. Portillo-Lara, J.L. Gifford, M.M. Fares, S.M. Mithieux, A.S. Weiss, Engineering a sprayable and elastic hydrogel adhesive with antimicrobial properties for wound healing, Biomaterials, 139 (2017) 229-243.